Estrogen and Depression

Hormonal fluctuations in both women and men account for their aberrations in their thinking, behavior, moods, and their sexuality, expressed in the symptoms of depression. The crucial question is: Given its close connection with depression, is estrogen an antidepressant? Research scientists have conducted various studies, which have indicated the impact of estrogen on the brain with respect to memory function and postmenopausal women. According to their studies, approximately 35 percent of women have mild premenstrual physical and depressive symptoms due to the rapid decline in estrogen level. Among the pathways, estrogen plays a critical role in the proper flow of blood to different parts of the brain, thereby instrumental in optimizing emotion, memory, and cognitive functions. Prior to the actual onset of menopause, estrogen level in women significantly decreases as much as 50 to 75 percent. This may explain why women not only experience depression twice as much as men do but also are two times more likely to be hospitalized in their lifetimes. This discrepancy has little to do with the fact that women seek psychiatric help more frequently than men do, or the fact that women are more stressed out than men are.

 

Following pregnancy, women also experience a drastic decline in estrogen level. Consequently, 50 to 70 percent women experience postpartum depression within the first 10 days following delivery, and approximately 10 percent may suffer a major depression. According to a study, more than 60 percent with postpartum depression may develop depression later in life. During menopause and perimenopause, women’s dramatic decline in estrogen level makes them more vulnerable to extreme mood swings. Many studies attest to the close link between estrogen and mood swings.

 

An NIH (National Institutes of Health) study on the role of estrogen as an antidepressant indicated that women patients receiving high-dose estrogen experienced significant improvement in their symptoms of depression. In addition, their improvement sustained beyond the study period. Scientists have to believe that estrogen and other hormones may benefit those patients with treatment-resistant depression. The rational is based on the assumption that antidepressants may only boost the “level” of neurotransmitters but without enhancing the “quality” of those transmitters, and therefore may not be efficacious in treating some depression, especially those with low estrogen and testosterone levels.

 

Studies have also indicated that patients suffering from anxiety, another mood-related disorder attributed to peri- and postmenopausal depression. Symptoms of anxiety, such as dry mouth, waking up in the middle of the night short of breath, excessive sweating, and nausea, can be relieved with estrogen treatment.

 

Other hormones that may play havoc with depression are testosterone and the thyroid hormone. Testosterone, which is responsible for energy and sexual function in women as well, has an antidepressant effect on the brain. Therefore, a decline in testosterone may precipitate depressive episodes. Disorder in the thyroid hormone may produce paranoid delusions in patients suffering from bipolar depression.

 

 

Natural Estrogen

 

This remarkable coenzyme, which occurs naturally in younger bodies, but gradually diminishes with age, may very well be one of your best defenses against disease and aging… 

 

 

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Hillary hit by depression while first lady

According to a new book by Carl Bernstein, Hillary Clinton, suffered from bouts of depression. Bernstein’s new expose, A Woman in Charge, details how she showed “persistent signs of melancholy” when she was a student and quotes a White House adviser saying she was “deeply depressed” in 1994, a year after her husband, Bill, became president. Such bouts are understood in the parlance of depression as “Situational Depression,” depression caused by a particular situation.

Bernstein’s book also delved into Senator Clinton’s complex relationship with her disciplinarian father, her early development of deep religious feelings, as well as her life at Wellesley and Yale Law School where her political ideals took shape. It also attempts to deconstruct her courtship with Bill Clinton and the amazing dynamic of their marriage; and how she was instrumental in the triumphs and troubles of Bill’s governorship and presidency. It also details her successful run for Senate and remarkable rise to a dominant role in the Democratic party, shedding light on her political brilliance as well as her blind spots.

The book goes on to state that Mrs. Clinton’s “emotional state” was “as fragile as it had ever been” in late 1994 after her close friend Vince Foster had committed suicide, her father had died, and her healthcare proposals had been rejected. It quotes David Gergen, then a senior Clinton aide, said,: “I don’t know whether she was seeing a doctor or not but she was depressed.”

Bernstein suggests that Mrs. Clinton experienced recurring “February depression” as a college student where she confided to Don Jones, a Methodist minister, as she would for the next three decades, including the year of her husband’s impeachment.

 

Carl Bernstein’s A Woman in Charge profiles Hillary Clinton

 

 

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Oleoyl-estrone and body fat

Another naturally circulating hormone found in humans. First researched at the University of Barcelona it was found to induce body-fat loss while preserving protein stores. This is important because most diets that induce fat loss are also responsible for protein loss as well. The ultimate goal of any diet agent is to preserve protein. Researchers are speculating that OE does so by lowering the body’s body fat set point which allows the body to maintain a reduced body fat without experiencing a hormonal response aimed at regaining lost body fat. OE is currently licensed to Manhattan Pharmaceuticals and Phase I trials were conducted in Switzerland. The results were promising. They showed OE to lead to some weight loss after just 7 days of dosing and most importantly in the treatment groups this weight loss was maintained for 3 further weeks after treatment had stopped. A Phase IIa trial of 100 patients are in motion.

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Growth Hormone / 7 Keto DHEA synergy

The decline of our fundamental hormones is directly associated with certain aging signs like shrinkling of the skin, graying of the hair, decreased energy and sexual function, increased body fat, heart disease, weak and brittle bones, and much more. The good news is that DHEA and growth hormone, when properly supplemented, can significantly relieve these physical signs and restore energy levels, bone strength, hair color, more youthful appearing skin, and for most people, an increased, youthful muscle mass while simultaneously reducing body fat.  As I mentioned earlier, DHEA enhances insulin-like growth factor -1 (IGF-1) release. IGF-1 (formerly called “Somatomedin C”) is the “hidden anabolic power behind the throne” of growth hormone (GH).

Human growth hormone is secreted by the anterior pituitary gland. In 1985, biosynthetic human growth hormone replaced pituitary-derived (the cadavers of dead babies) human growth hormone for therapeutic use in the U.S. and elsewhere. Biosynthetic human growth hormone, also referred to as recombinant human growth hormone, somatropin and is abbreviated as rhGH.

Growth hormone can generally be described as anabolic (building up). Like most other protein hormones GH acts by interacting with a specific receptor on the surface of cells. Although height growth is the best known effect of GH, it serves many other metabolic functions as well.

GH increases calcium retention, and strengthens and increases the mineralization of bone. It increases muscle mass through the creation of new muscle cells (which differs from hypertrophy), and it also promotes lipolysis, which results in the reduction of adipose tissue (body fat). As well, it increases protein synthesis and stimulates the growth of all internal organs excluding the brain.

Deficiency of GH produces significantly different problems at various ages. In children, growth failure and short stature are the major manifestations of GH deficiency. In adults the effects of deficiency are more subtle, and may include deficiencies of strength, energy, and bone mass, as well as increased cardiovascular risk.

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7 Keto DHEA

7-keto DHEA  (also called “7-oxo DHEA,)” is almost identical in structure to DHEA is a safe metabolite of DHEA that does not convert into androgens or estrogens.  It is like a predigested version of DHEA that has been cleaned up, denuded of its harmful anabolic properties. Interestingly, when applied topically to our skin, some of it is converted into 7 Keto DHEA.

7 Keto DHEA sits at the helm of the endocrine system, a platform that it shares with Growth Hormone. 7- keto DHEA increases thermogenic enzymes in the liver. It has been demonstrated to increase IL-2 production better than DHEA, in human lymphocytes.  IL-2 is the key cytokine regulator of T-helper cells. It activates the immune system to “go into battle” against invading pathogens.

In terms of fat reduction and energy: 7-keto-DHEA decreases the efficiency of energy production in the body meaning that more fats have to be burned to produce the same amount of useable energy. This results in loss of fat. To achieve this result doses of 350 to 1400 mg/day must be used. It is especially powerful when taken in conjunction with Homeopathic HGH.

Immunity: 7-keto-DHEA treatment caused an increase in anti-viral antibodies to some of the viruses however a proper dosage level has not been determined.

Hormonal effects: 7-keto-DHEA does not metabolize to estrogens or testosterone.

Safety: The only side effect (of very high doses) of this substance appears to be excess salivation in monkeys.

Human Growth Hormone (HGH) is one of many endocrine hormones such as testosterone, estrogen, melatonin, and DHEA, which decline in production with age. While some of these hormones can reduce the effects of aging, only HGH and IGF-1 go far beyond the scope of the other hormones to prevent biological aging and also to reverse a broad range of symptoms associated with aging and even certain diseases of aging.

 

 

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DHEA / 7-keto DHEA Growth Hormone and safe synergy

Thousands of scientific articles have been published about this powerful hormone’s anti-depression, anti-obesity, anti-carcinogenic, anti-stress, immune-enhancing, anti-viral and anti-bacterial, anti-aging and anti-heart disease effects. DHEA’s reach into the human condition is so penetrating and powerful that it could easily fill books of encyclopedic proportions. Start anywhere. DHEA enhances insulin-like growth factor -1 (IGF-1) release. IGF-1 (formerly called “Somatomedin C”) is the “hidden anabolic power behind the throne” of growth hormone (GH).  The now famous Morales/Yen study found that DHEA boosted a 10% rise in serum IGF-1 levels. At the same time it has shown anti cortisol effects. You will recall that cortisol is the stress hormone that causes a build up in the mid section of the body.

So, why doesn’t everyone supplement with DHEA? Too much crude DHEA significantly boosts androgen and estrogen. The androgen can potentially cause facial hair in women, acne, enlarged clitoris, abdominal fat, hyper-glycemia and insulin resistance, and breasts in men. I don’t think anyone needs another reason not to take it.

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