Hypericum’s – HBC Protocols All natural depression treatment

Natural depression tretment -St. John’s wort

Prior exposure to oxytocin mimics the effects of social contact and facilitates sexual behaviour in females

Power of love_1_300The purpose of this study was to determine whether pretreatment with oxytocin could mimic the effects of social contact and enhance sexual receptivity in female prairie voles. Female prairie voles require prolonged exposure to males to become sexually active and oxytocin has been shown to play a major role in the establishment of social bonds between males and females. Therefore, we hypothesized that prior exposure to exogenous oxytocin, in the absence of males, would enhance sexual activity in females. Two experiments were conducted to test this hypothesis. Experiment 1 examined the capacity of oxytocin to enhance sexual behaviour in females undergoing natural oestrus. Sexually naive female prairie voles Power of love_2received a daily subcutaneous injection of 20 microg oxytocin or isotonic saline for 5 days before being placed with a sexually experienced male for 48 h. Females treated with oxytocin were significantly more likely to mate during this period than saline-treated females. In experiment 2 the ability of oxytocin to increase subsequent sensitivity of sexually naive females to oestradiol was tested. Females that received oxytocin pretreatment, as in experiment 1, followed by oestradiol displayed a significant increase in sexual receptivity when compared to females treated with saline and oestradiol or oestradiol only. The results supported the hypothesis that prior exposure to oxytocin can mimic the effects of social contact, and can facilitate sexual receptivity by increasing the sensitivity of females to very low doses of oestradiol.

Cushing BS, Carter CS.
Department of Biology,
University of Maryland, College Park,
MD 20742, USA.
bc83@umail:umd.edu
J Neuroendocrinol 1999 Oct;11(10):765-9

Oxytocin is an FDA controlled substance!

Click here to read about a sublingual Homeopatic

formulation designed to enable the body to release and  Accelerate its own Natural Oxytocin.

 
Click here to comment this article Comment
 

August 6, 2008 Posted by | 5-htp, 7-keto, anti-alcohol antioxidant, antidepressants, antioxidants, anxiety, brain antioxidant, carbo blocker, coral calcium, Depression, depression medication, drugs, Healt care, help, hgh patch, hypericum, idebenone, lithium orotate, postpartum, SAMe 400, Siberian Ginseng, St John's wort, teen, treating depression, treatment, treatments, vitamins | Leave a comment

Oxytocin may mediate the benefits of positive social interaction and emotions

Emotions_1_300During breastfeeding or suckling, maternal oxytocin levels are raised by somatosensory stimulation. Oxytocin may, however, also be released by nonnoxious stimuli such as touch, warm temperature etc. in plasma and in cerebrospinal fluid. Consequently, oxytocin may be involved in physiological and behavioral effects induced by social interaction in a more general context. In both male and female rats oxytocin exerts potent physiological antistress effects. If daily oxytocin injections are repeated over a 5-day period, blood pressure is decreased by 10-20 mmHg, the withdrawal latency to heat stimuli is prolonged, cortisol levels are decreased and insulin and cholecystokinin levels are increased. These effects last from 1 to several weeks after the last injection. After repeated oxytocin treatment weight gain may be promoted and the healing rate of Emotions_2_300wounds increased. Most behavioral and physiological effects induced by oxytocin can be blocked by oxytocin antagonists. In contrast, the antistress effects can not, suggesting that unidentified oxytocin receptors may exist. The prolonged latency in the tail-flick test can be temporarily reversed by administration of naloxone, suggesting that endogenous opioid activity has been increased by the oxytocin injections. In contrast, the long-term lowering of blood pressure and of cortisol levels as well as the sedative effects of oxytocin have been found to be related to an increased activity of central alpha 2-adrenoceptors. Positive social interactions have been related to health-promoting effects. Oxytocin released in response to social stimuli may be part of a neuroendocrine substrate which underlies the benefits of positive social experiences. Such processes may in addition explain the health-promoting effects of certain alternative therapies. Because of the special properties of oxytocin, including the fact that it can become conditioned to psychological state or imagery, oxytocin may also mediate the benefits attributed to therapies such as hypnosis or meditation.

Uvnas-Moberg K
Department of Physiology and Pharmacology,
Karolinska Institute,
Stockholm, Sweden.
kerstin.uvnas-moberg@fyka.ki.se
Psychoneuroendocrinology 1998 Nov; 23(8):819-35

Oxytocin is an FDA controlled substance!

Click here to read about a sublingual Homeopatic formulation designed to enable the body to release and Accelerate its own Natural Oxytocin.
Click here to comment this article Comment

August 6, 2008 Posted by | 5-htp, 7-keto, anti-alcohol antioxidant, antidepressants, antioxidants, anxiety, brain antioxidant, carbo blocker, coral calcium, Depression, depression medication, drugs, Healt care, help, hgh patch, hypericum, idebenone, lithium orotate, postpartum, SAMe 400, Siberian Ginseng, St John's wort, teen, treating depression, treatment, treatments, vitamins | , , , , , , , , , , , , , | Leave a comment

Role of oxytocin in the neuroadaptation

Neuroadaptation_1_300Oxytocin (OXT), a neurohypophyseal hormone, has a wide range of behavioral effects outside its classic peripheral endocrine functions. OXT involvement in adaptive central nervous system processes has been demonstrated as an inhibitory, amnestic action on learning and memory in different paradigms. Because adaptation and learning are likely to be involved in the neural events leading to drug tolerance and dependence, the question logically arose whether OXT is able to influence the development of tolerance of and dependence on abused drugs. In this review, we summarize our results on the effects of OXT on opiate (including morphine, heroin, and the endogenous opiates beta-endorphin and enkephalin) tolerance and dependence, heroin self-administration, psychostimulant-induced behavioral changes, and behavioral tolerance and sensitization. The sites and mechanisms of action and the possible physiological role of OXT are also discussed. In the first part of this review the Neuroadaptation_2effects of exogenously administered OXT on both the acute and chronic behavioral effects of opiates and psychostimulants have been summarized. OXT inhibited the development of tolerance to morphine, heroin, beta-endorphin, and enkephalin, OXT also inhibited the development of cross-tolerance between the predominantly mu-agonist heroin and the predominantly delta-agonist enkephalin in mice. Naloxone-precipitated morphine withdrawal syndrome was also attenuated by OXT. Heroin self-administration was decreased by OXT administration in heroin-tolerant rats. OXT inhibited cocaine-induced exploratory activity, locomotor hyperactivity, and stereotyped behavior in rats and in mice. Behavioral tolerance to cocaine was also attenuated by OXT. On the contrary, OXT stimulated the development of behavioral sensitization to cocaine. OXT did not alter the stereotyped behavior induced by amphetamine. In the second series of experiments, the sites of action of OXT on drug-related behavior were investigated. Intracerebro-ventricular (ICV) and intracerebral (IC) administration of an OXT-receptor antagonist inhibited the effects of peripherally administered OXT on morphine tolerance, heroin self-administration, and cocaine-induced sniffing behavior. Neuroadaptation_3_300This suggests the central, intracerebral location of OXT target sites. Local IC microinjection of OXT in physiological doses into the posterior olfactory nucleus, tuberculum olfactorium, nucleus accumbens, central amygdaloid nucleus, and the hippocampus inhibited the development of tolerance to and dependence on morphine as well as cocaine-induced sniffing behavior and tolerance to cocaine. The physiological role of endogenous OXT in acute morphine tolerance has also been demonstrated, since OXT antiserum (ICV) and OXT-receptor antagonist (injected into the basal forebrain structures) potentiated the development of morphine tolerance. Finally, we investigated the possible mechanisms of action of OXT on drug related behavior. Both morphine tolerance and dependence, and cocaine administration, increased dopamine utilization in the mesencephalon and in the nucleus accumbens, respectively. OXT treatment decreased the alpha-methylparatyrosine-induced dopamine utilization in the mesencephalon and in the nucleus accumbens-septal complex. Chronic OXT treatment decreased the number of apparent binding sites of dopamine in the basal forebrain area. It also inhibited a cocaine-induced increase in dopamine utilization in the nucleus accumbens, but not in the striatum. In light of this information, it appears that OXT inhibits the development of opiate tolerance, dependence, and self-administration as well as the acute behavioral actions of and chronic tolerance to cocaine. This suggests the possible role of this neuropeptide in the regulation of drug abuse. Therefore, OXT may act as a neuromodulator on dopaminergic neurotransmission in limbic-basal forebrain structures to regulate adaptive CNS processes leading to drug addiction.

Sarnyai Z, Kovacs GL
Alcohol and Drug Abuse Research Center,
Harvard Medical School-McLean Hospital,
Belmont, MA 02178, USA.
Psychoneuroendocrinology 1994; 19(1):85-117

Oxytocin is an FDA controlled substance!

Click here to read about a sublingual Homeopatic formulation designed to enable the body to release and  Accelerate its own Natural Oxytocin.

Click here to comment this article Comment

August 6, 2008 Posted by | 5-htp, 7-keto, anti-alcohol antioxidant, antidepressants, antioxidants, anxiety, brain antioxidant, carbo blocker, coral calcium, Depression, depression medication, drugs, Healt care, help, hgh patch, hypericum, idebenone, lithium orotate, postpartum, SAMe 400, Siberian Ginseng, St John's wort, teen, treating depression, treatment, treatments, vitamins | Leave a comment

Research on plasma oxytocin in normal cycling women: investigating emotion and interpersonal distress

Emotion and interperson_1The neurohormone oxytocin is responsible for initiating childbirth and the let-down reflex in lactating women and is released during sexual orgasm. Oxytocin has been thought of as an affiliation hormone because research on nonhuman mammals has demonstrated that it plays a key role in the initiation of maternal behavior and the formation of adult pair bonds. It has been speculated that social stimuli may induce oxytocin release and that oxytocin may make positive social contact more rewarding. Data are presented from an initial study to Emotion and interperson_2examine change in plasma oxytocin in response to a standard imagery task that elicits emotion related to attachment. Twenty-five normal cycling, healthy women underwent imagery tasks and completed questionnaires on attachment and interpersonal problems. Blood draws (5 ml) were bone via an indwelling catheter before, during, and after three interventions (massage, positive emotion, and negative emotion) and to establish baselines. Overall, the data showed a tendency for Emotion and interperson_3oxytocin levels to be elevated in response to relaxation massage and decreased in response to sad emotion. There were individual differences in response to the interventions. Those who showed evidence of increased oxytocin levels for positive emotion and massage and who maintained oxytocin levels during negative emotion were less likely to report interpersonal problems associated with intrusiveness. Maintaining oxytocin levels during sadness was also correlated with lower anxiety in close relationships. Women who were in a couple relationship had greater increases in oxytocin in response to positive emotion. In contrast, higher basal levels of oxytocin were associated with greater interpersonal distress. These data suggest that peripheral secretion of oxytocin in response to emotional stimuli is associated with the individual’s interpersonal characteristics.

Turner RA, Altemus M, Enos T, Cooper B, McGuinness T
California School of Professional Psychology,
San Francisco, USA.
beckyt@itsa.ucsf.edu
Psychiatry 1999 Summer; 62(2):97-113

Oxytocin is an FDA controlled substance!

Click here to read about a sublingual Homeopatic formulation designed to enable the body to release and  Accelerate its own Natural Oxytocin.

Click here to comment this article Comment

August 6, 2008 Posted by | 5-htp, 7-keto, anti-alcohol antioxidant, antidepressants, antioxidants, anxiety, brain antioxidant, carbo blocker, coral calcium, Depression, depression medication, drugs, Healt care, help, hgh patch, hypericum, idebenone, lithium orotate, postpartum, SAMe 400, Siberian Ginseng, St John's wort, teen, treating depression, treatment, treatments, vitamins | Leave a comment