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Oxytocin and paradise engineering.

Paradise_engineering_300x200Known as oxytocin (not to be confused with the painkiller OxyContin), the naturally occurring hormone is best known for controlling contractions during labor, but it also plays a key role in other fundamental human urges — including the desire to connect with others. “Somehow, the peptide increases trust, or alters the way individuals see each other,” says Tom Insel, director of the National Institute of Mental Health.

Without oxytocin people would be far less inclined to seek social interaction, let alone fall in love and mate for life (or, as scientists call it, “pair bond”). The brain releases gobs of it during orgasm, mothers are awash in it during breastfeeding and, in clinical trials, a spritz of oxytocin has been shown to reduce anxiety, increase feelings of generosity and even ease the symptoms of shyness. Conversely, researchers are beginning to discover that low levels of the hormone — or the body’s faulty response to it — may contribute to severe social dysfunctions like depression and autism.

Paradise_engineering_2Most previous research on oxytocin has focused on animals. (Prairie voles are famous for their oxytocin-inspired behavior: they’re fiercely monogamous lovers and caring parents.) But more recently, scientists have begun to determine how oxytocin functions in the human brain — or, more specifically, how it malfunctions. Studies have shown that people with autism tend to have low levels of oxytocin, as well as hyperactivity in the amygdala, where most oxytocin receptors are located. The amygdala is also where memories are formed, and where our brains process and assign emotional meaning to sensory information — that is, where we turn perception (seeing someone smile) into “neuroception” (understanding the feeling of happiness that the smile reflects), says Stephen Porges, a psychologist at the University of Illinois in Chicago. So, misfirings in the amygdala, in tandem with low oxytocin, may help explain why people with autism have trouble distinguishing between happy expressions and angry ones, making social interaction difficult and unpleasant.

Paradise_engineering_3Early studies of oxytocin’s role in social interaction have yielded some interesting results. In a small 2006 experiment, Dr. Eric Hollander of New York’s Mount Sinai School of Medicine administered synthetic oxytocin and a placebo intravenously to 15 autistic adult patients; afterward, those who received oxytocin were better able to decipher emotions in tone of voice. Moreover, these improvements in social awareness lasted for nearly two weeks. (In 2006, Hollander filed a patent for the use of oxytocin to treat symptoms of autism spectrum disorders; the request is still pending). Investigators at Mount Sinai have also found that oxytocin nasal sprays enhance autistic patients’ ability to interpret facial expressions.

The effects of oxytocin nasal spray are not limited to those with autism either. In studies by Paul Zak, director of the Center for Neuroeconomics Studies in Claremont, Calif., small doses of inhaled oxytocin spray reduced anxiety and wariness of strangers in healthy volunteers; in one trial, the hormone made people feel more generous and trusting with their money.

For the oxytocin-deficient among us, the hormone is commercially available on the Internet. It ought to make love, lust or trust bloom a little faster.That’s not unlike the drug ecstasy, which triggers the release of serotonin, dopamine and oxytocin in the brain and heightens users’ feelings of trust and intimacy, even among complete strangers. Concerns that oxytocin might be similarly abused as a recreational drug seem unfounded. Though oxytocin is something of a wonder compound, it is only one piece of social support. It should be used in conjunction with: massage, talking, or “mind-body,” therapies, like breathing exercises and yoga, which help people cope with their emotions by controlling their body’s physical reaction to stress and fear. Preliminary findings are intriguing, though some oxytocin researchers remain skeptical about the notion of “paradise engineering.”

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July 24, 2008 Posted by | 5-htp, 7-keto, anti-alcohol antioxidant, antidepressants, antioxidants, anxiety, brain antioxidant, carbo blocker, coral calcium, Depression, depression medication, drugs, Healt care, help, hgh patch, hypericum, idebenone, lithium orotate, postpartum, SAMe 400, Siberian Ginseng, St John's wort, teen, treating depression, treatment, treatments, vitamins | , , , , , , , , , , | Leave a comment